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What happens if HLA b27 is positive? A negative result mean you don't have HLA - B27 in your blood. A positive result means HLA - B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis.
Can a blood test detect ankylosing spondylitis? Only 30–40% of people with ankylosing spondylitis have inflammation that can be picked up in a blood test, so in many cases these blood tests will be normal. Another blood test can confirm whether you have the HLA-B27 gene. A positive test may point to AS but it won't confirm the diagnosis.